Telisotuzumab
Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers[1].
Product Specifications
CAS Number
1781223-80-0
Product Name Alternative
ABT-700
UNSPSC
12352203
Target
Apoptosis; c-Met/HGFR
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/telisotuzumab.html
Purity
99.54
Solubility
10 mM in DMSO
Smiles
[Telisotuzumab]
Molecular Weight
(146.1 kDa)
References & Citations
[1]Jieyi Wang, et al. Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification. BMC Cancer. 2016 Feb 16;16:105.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3
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