TLR7 agonist 3

TLR7 agonist 3 (compound 2) is a TLR7 agonist. TLR7 agonist 3 (compound 5) can be coupled to folate receptor binding ligands to target myeloid-derived suppressor cells and exert anticancer activity[1][2].

Product Specifications

CAS Number

[1229024-78-5]

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tlr7-agonist-3.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : ≥ 50 mg/mL

Smiles

CC(O)(C)CN1C(CCCC)=NC2=C1C3=CC=CC=C3N=C2N

Molecular Formula

C18H24N4O

Molecular Weight

312.41

References & Citations

[1]Urban Švajger, et al. New antagonists of toll-like receptor 7 discovered through 3D ligand-based virtual screening. Medicinal Chemistry Research. 2015. 24: 362-371.|[2]Method of treating cancer by targeting myeloid-derived suppressor cells comprising a folate receptor binding ligand attached to a drug via a linker. World Intellectual Property Organization, WO2017205661 A1 2017-11-30.