Pyruvate Carboxylase-IN-1
Product Specifications
UNSPSC Description
Pyruvate Carboxylase-IN-1 (compound 37) is a potent pyruvate carboxylase inhibitor with antiproliferative activity. The IC50 values of pyruvate carboxylase-IN-1 against PC in cell lysates and cells are 0.204 and 0.104 μM, respectively[1].
Target Antigen
Mitochondrial Metabolism; Others
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pyruvate-carboxylase-in-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C=C(OC)C=C1CC2)=C1C3=C2C=CC=C3O
Molecular Weight
242.27
References & Citations
[1]Sheng Y, et al. Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming. J Med Chem. 2022;65(1):460-484.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142684/Pyruvate-Carboxylase-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142684/Pyruvate-Carboxylase-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
70205-50-4
Available Sizes
Curated Selection
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