Pyruvate Carboxylase-IN-1

Pyruvate Carboxylase-IN-1 (compound 37) is a potent pyruvate carboxylase inhibitor with antiproliferative activity. The IC50 values of pyruvate carboxylase-IN-1 against PC in cell lysates and cells are 0.204 and 0.104 μM, respectively[1].

Product Specifications

CAS Number

[70205-50-4]

UNSPSC

12352005

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pyruvate-carboxylase-in-1.html

Purity

99.43

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C=C(OC)C=C1CC2)=C1C3=C2C=CC=C3O

Molecular Formula

C15H14O3

Molecular Weight

242.27

References & Citations

[1]Sheng Y, et al. Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming. J Med Chem. 2022;65 (1) :460-484.