Pyruvate Carboxylase-IN-1
Pyruvate Carboxylase-IN-1 (compound 37) is a potent pyruvate carboxylase inhibitor with antiproliferative activity. The IC50 values of pyruvate carboxylase-IN-1 against PC in cell lysates and cells are 0.204 and 0.104 μM, respectively[1].
Product Specifications
CAS Number
[70205-50-4]
UNSPSC
12352005
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pyruvate-carboxylase-in-1.html
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C=C(OC)C=C1CC2)=C1C3=C2C=CC=C3O
Molecular Formula
C15H14O3
Molecular Weight
242.27
References & Citations
[1]Sheng Y, et al. Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming. J Med Chem. 2022;65 (1) :460-484.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
H00054600-P01-2ug 2 µg
Recombinant Human UGT1A9 Protein - (Dry Ice)
Sign In for Pricing
View Details 
LV654214 1.0 µg DNA
AGR3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
Sign In for Pricing
View Details ![Mouse Monoclonal Flt-3/Flk-2/CD135 Antibody (MM0294-9G23) [Janelia Fluor 549]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
NBP2-12311JF549 0.1 mL
Mouse Monoclonal Flt-3/Flk-2/CD135 Antibody (MM0294-9G23) [Janelia Fluor 549]
Sign In for Pricing
View Details 
GTR15241603 1 Vial
Lentiviral mouse Htr5a shRNA (UAS) - Lentiviral mouse Htr5a shRNA (UAS) plasmid
Sign In for Pricing
View Details K6176508 1.0 µg DNA
Rnf125 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)
Sign In for Pricing
View Details