AP1867-2- (carboxymethoxy)
AP1867-2- (carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules[1].
Product Specifications
CAS Number
[2230613-03-1]
Product Name Alternative
PROTAC FKBP12-binding moiety 2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FKBP; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-fkbp12-ligand-1.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(O)=O)CCC4=CC=C(OC)C(OC)=C4
Molecular Formula
C38H47NO11
Molecular Weight
693.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14 (5) :431-441.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12
Available Sizes
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