PROTAC SMARCA2 degrader-19
PROTAC SMARCA2 degrader-19 (Compound 46) is a PROTAC degrader for SMARCA2, that degrades SMARCA2 in cell A549 and MV411 with a DC50 SMARCA4 in cell MV411 with a DC50 > 1000 nM[1].
Product Specifications
CAS Number
2567913-00-0
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-19.html
Smiles
OC1=C(C=CC=C1)C2=NN=C3NC=C(C4CCN(C5=NC=C([C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)=O)C=N5)CC4)C3=C2
Molecular Formula
C50H58N10O5S
Molecular Weight
911.12
References & Citations
[1]Ji, et al., Smarca degraders and uses thereof. WO2020251972.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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