PROTAC SMARCA2 degrader-19
PROTAC SMARCA2 degrader-19 (Compound 46) is a PROTAC degrader for SMARCA2, that degrades SMARCA2 in cell A549 and MV411 with a DC50 SMARCA4 in cell MV411 with a DC50 > 1000 nM[1].
Product Specifications
CAS Number
2567913-00-0
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-19.html
Smiles
OC1=C(C=CC=C1)C2=NN=C3NC=C(C4CCN(C5=NC=C([C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)=O)C=N5)CC4)C3=C2
Molecular Formula
C50H58N10O5S
Molecular Weight
911.12
References & Citations
[1]Ji, et al., Smarca degraders and uses thereof. WO2020251972.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC042937-100 1x 100 µL
CD47 / IAP (Integrin Associated Protein) (CD47/2937), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
