Etiocholanolone
Product Specifications
UNSPSC Description
Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent?neurosteroid positive allosteric modulator?(PAM) of the GABAA?receptor than its?enantiomer form[2].
Target Antigen
Endogenous Metabolite; GABA Receptor
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/etiocholanolone.html
Purity
99.31
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C[C@@]1(CC2)[C@](CC3)([H])[C@](CC[C@]1([H])C[C@@H]2O)([H])[C@@](CCC4=O)([H])[C@]34C
Molecular Weight
290.44
References & Citations
[1]Ping Li,et al. Natural and Enantiomeric Etiocholanolone Interact With Distinct Sites on the Rat alpha1beta2gamma2L GABAA Receptor. Mol Pharmacol. 2007 Jun;71(6):1582-90.|[2]Dorota Zolkowska, et al. Anticonvulsant Potencies of the Enantiomers of the Neurosteroids Androsterone and Etiocholanolone Exceed Those of the Natural Forms. Psychopharmacology (Berl). 2014 Sep;231(17):3325-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113320/Etiocholanolone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113320/Etiocholanolone-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
53-42-9
Available Sizes
Curated Selection
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