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(E/Z) -CCR-11

(E/Z) -CCR-11 (Comp 12) is a selective CD38 inhibitor, with an IC50 of 20.8 μM against CD38 cyclase. (E/Z) -CCR-11 promotes increases in cellular NAD+ levels and interferon γ[1].

Product Specifications

CAS Number

301687-87-6

Product Name Alternative

BE-34776

UNSPSC

12352005

Target

CD38

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/e-z-ccr-11.html

Purity

98.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC(S/C1=C\C2=CC=C(C3=CC(C(F)(F)F)=CC=C3)O2)=S

Molecular Formula

C15H8F3NO2S2

Molecular Weight

355.35

References & Citations

[1]Thomas Z Benton, et al. Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation. RSC Adv. 2021 Oct 11;11 (53) :33260-33270.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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