(E/Z) -CCR-11
(E/Z) -CCR-11 (Comp 12) is a selective CD38 inhibitor, with an IC50 of 20.8 μM against CD38 cyclase. (E/Z) -CCR-11 promotes increases in cellular NAD+ levels and interferon γ[1].
Product Specifications
CAS Number
301687-87-6
Product Name Alternative
BE-34776
UNSPSC
12352005
Target
CD38
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/e-z-ccr-11.html
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC(S/C1=C\C2=CC=C(C3=CC(C(F)(F)F)=CC=C3)O2)=S
Molecular Formula
C15H8F3NO2S2
Molecular Weight
355.35
References & Citations
[1]Thomas Z Benton, et al. Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation. RSC Adv. 2021 Oct 11;11 (53) :33260-33270.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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