PY-60
Product Specifications
UNSPSC Description
PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 µM. PY-60 directly binds to ANXA2 and antagonizes its normal cellular function of repressing YAP activity[1].
Target Antigen
Annexin A; YAP
Type
Reference compound
Related Pathways
Cytoskeleton;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/py-60.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NOC(C2=CC=CC=C2)=C1)NCCCC3=NC=CS3
Molecular Weight
313.37
References & Citations
[1]Shalhout SZ, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021;17(7):767-775.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141644/PY-60-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141644/PY-60-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2765218-56-0
Available Sizes
Curated Selection
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