PY-60
PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 µM. PY-60 directly binds to ANXA2 and antagonizes its normal cellular function of repressing YAP activity[1].
Product Specifications
CAS Number
[2765218-56-0]
UNSPSC
12352005
Target
Annexin A; YAP
Type
Reference compound
Related Pathways
Cytoskeleton; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/py-60.html
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NOC(C2=CC=CC=C2)=C1)NCCCC3=NC=CS3
Molecular Formula
C16H15N3O2S
Molecular Weight
313.37
References & Citations
[1]Shalhout SZ, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021;17 (7) :767-775.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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