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PY-60

PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 µM. PY-60 directly binds to ANXA2 and antagonizes its normal cellular function of repressing YAP activity[1].

Product Specifications

CAS Number

2765218-56-0

UNSPSC

12352005

Target

Annexin A; YAP

Type

Reference compound

Related Pathways

Cytoskeleton; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/py-60.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NOC(C2=CC=CC=C2)=C1)NCCCC3=NC=CS3

Molecular Formula

C16H15N3O2S

Molecular Weight

313.37

References & Citations

[1]Shalhout SZ, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021;17 (7) :767-775.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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