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RO6806051

RO6806051 (compound 12) is a potent dual inhibitor of fatty acid binding protein 4 and 5 (FABP4 and FABP5), with Ki values of 0.011 and 0.086 μM for hFABP4 and hFABP5, respectively. It exhibits good selectivity and favorable absorption, distribution, metabolism, and excretion (eADME) properties[1].

Product Specifications

CAS Number

[1433901-75-7]

UNSPSC

12352005

Target

FABP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ro6806051.html

Purity

99.84

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

ClC1=CC2=C(N=C(N3CCCCC3)C(C4=NN=NN4)=C2C5=CC=CC=C5)C=C1

Molecular Formula

C21H19ClN6

Molecular Weight

390.87

References & Citations

[1]Kühne H, et al. Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors. Bioorg Med Chem Lett. 2016 Oct 15;26 (20) :5092-5097.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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