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Morin

Morin is an orally active plant-derived flavonoid. Morin inhibits ROS generation. Morin induces Apoptosis. Morin inhibits PTP1B (IC50 of 15 μM) and activates the insulin receptor. Morin has a detoxifying effect. Morin can be used in diabetes, leukemia, colon cancer, cervical cancer, Parkinson's disease and hypertension research[1][2][3][4][5][6][7][8][9][10][11][12].

Product Specifications

CAS Number

[480-16-0]

UNSPSC

12352005

Hazard Statement

H411

Target

Apoptosis; Insulin Receptor; Phosphatase; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/morin.html

Purity

98.11

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=C(O)C=C2O)OC3=CC(O)=CC(O)=C13

Molecular Formula

C15H10O7

Molecular Weight

302.24

Precautions

H411

References & Citations

[1]Duthie G, et al. Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo. Oxid Med Cell Longev. 2012;2012:165127.|[2]Lian HZ, et al. Morin applied in speciation of aluminium in natural waters and biological samples by reversed-phase high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem. 2003 Jun;376 (4) :542-8. Epub 2003 May 9.|[3]Zhang R, et al. Cellular protection of morin against the oxidative stress induced by hydrogen peroxide. Chem Biol Interact. 2009 Jan 15;177 (1) :21-7.|[4]Kuo HM, et al. Morin inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway. Anticancer Res. 2007 Jan-Feb;27 (1A) :395-405.|[5]Paoli P, et al. The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment. Biochim Biophys Acta. 2013 Apr;1830 (4) :3102-11.|[6]Zhang Q, et al. Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells. Food Chem Toxicol. 2018 Feb;112:466-475. |[7]Zhang ZT, et al. Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo. Acta Pharmacol Sin. 2010 Aug;31 (8) :900-6.|[8]Parihar VK, et al. Anticlastogenic activity of morin against whole body gamma irradiation in Swiss albino mice. Eur J Pharmacol. 2007 Feb 14;557 (1) :58-65.|[9]Merwid-Ląd A, et al. The effects of morin, a naturally occurring flavonoid, on cyclophosphamide-induced toxicity in rats. Advances in Clinical and Experimental Medicine, 2011, 20 (6) : 683-690. |[10]Prahalathan P, et al. Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study. Asian Pac J Trop Biomed. 2012 Jun;2 (6) :443-8. |[11]Kuzu M, et al. Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis. Biomed Pharmacother. 2018 Oct;106:443-453.|[12]Sreedharan V, et al. Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis. Invest New Drugs. 2009 Feb;27 (1) :21-30.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-N0621/Morin-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-N0621/Morin-SDS-MedChemExpress.pdf

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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