VRX0466617
VRX0466617 is a selective and ATP-competitive Chk2 inhibitor with an IC50 of 120 nM and a Ki of 11 nM. VRX0466617 does not inhibit the related Chk1 activity. VRX0466617 can be used in the study of cancer.
Product Specifications
CAS Number
[926906-64-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vrx0466617.html
Purity
99.91
Solubility
10 mM in DMSO
Smiles
OCC(C)NC(C(C(NS1)=O)=C1NC2=CC=C(NC3=CC=C(Br)C=C3)C=C2)=N
Molecular Formula
C19H20BrN5O2S
Molecular Weight
462.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Carlessi L, et al. Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther. 2007 Mar;6 (3) :935-44.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7155146 Inquire
Rabbit anti-Escherichia coli (strain K12) YICH Polyclonal Antibody
Ask
View Details 
GTR15303936 1 Vial
Lentiviral mouse Sval2 shRNA (UAS) - Lentiviral mouse Sval2 shRNA (UAS, GFP) (100)
Ask
View Details 