VRX0466617

VRX0466617 is a selective and ATP-competitive Chk2 inhibitor with an IC50 of 120 nM and a Ki of 11 nM. VRX0466617 does not inhibit the related Chk1 activity. VRX0466617 can be used in the study of cancer.

Product Specifications

CAS Number

[926906-64-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vrx0466617.html

Purity

99.91

Solubility

10 mM in DMSO

Smiles

OCC(C)NC(C(C(NS1)=O)=C1NC2=CC=C(NC3=CC=C(Br)C=C3)C=C2)=N

Molecular Formula

C19H20BrN5O2S

Molecular Weight

462.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Carlessi L, et al. Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther. 2007 Mar;6 (3) :935-44.