FR-181877
FR-181877 (compound 4) is a non-prostaglandin PGI2 agonist. FR-181877 inhibits ADP -induced human platelet aggregation with an IC50 value of 0.081 μM[1].
Product Specifications
CAS Number
172936-99-1
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fr-181877.html
Smiles
OC(COC1=C(CC2)C(C[C@H]2CN(C(C=C3)=O)N=C3C(C4=CC=CC=C4)C5=CC=CC=C5)=CC=C1)=O
Molecular Formula
C30H28N2O4
Molecular Weight
480.55
References & Citations
[1]Tsubaki K, et al. A novel pyridazinone derivative as a nonprostanoid PGI2 agonist[J]. Bioorganic & medicinal chemistry letters, 2000, 10 (24) : 2787-2790.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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