DCP-LA

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca (2+) /calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis[1][2][3].

Product Specifications

CAS Number

[28399-31-7]

Product Name Alternative

FR236924

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; CaMK; Phosphatase; PKC

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/DCP-LA.html

Purity

98.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CCCCCCCC1C(CC2C(CCCCC)C2)C1

Molecular Formula

C20H36O2

Molecular Weight

308.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Kanno T, et al. DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain. Cell Physiol Biochem. 2015;37 (1) :193-200.|[2]Kanno T, et al. DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition. J Cell Physiol. 2009 Oct;221 (1) :183-8. |[3]Yaguchi T, et al. Linoleic acid derivative DCP-LA protects neurons from oxidative stress-induced apoptosis by inhibiting caspase-3/-9 activation. Neurochem Res. 2010 May;35 (5) :712-7.