PXS-4787 (hydrochloride)

PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 hydrochloride inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively. PXS-4787 hydrochloride reduces deposition and crosslinking of collagen I secreted by human fibroblasts[1].

Product Specifications

CAS Number

[2409964-40-3]

UNSPSC

12352211

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pxs-4787-hydrochloride.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

NC/C=C(CS(=O)(C1=CC=CC=C1)=O)\F.Cl

Molecular Formula

C10H13ClFNO2S

Molecular Weight

265.73

References & Citations

[1]Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13 (1) :5555.|[2]Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13 (1) :5555.