AV123
Product Specifications
UNSPSC Description
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 μM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1].
Target Antigen
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/av123.html
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CC=C2C(NC(NCCCC)=N2)=C1)[O-]
Molecular Weight
234.25
References & Citations
[1]Benchekroun M, et al. Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1. Eur J Med Chem. 2020 Sep 1;201:112337.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151369/AV123-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151369/AV123-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
233605-81-7
Available Sizes
Curated Selection
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PPP1R13B, ID (PPP1R13B, ASPP1, KIAA0771, Apoptosis-stimulating of p53 protein 1, Protein phosphatase 1 regulatory subunit 13B) (Biotin)
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PPP1R13B, ID (PPP1R13B, ASPP1, KIAA0771, Apoptosis-stimulating of p53 protein 1, Protein phosphatase 1 regulatory subunit 13B) (Biotin)
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