AV123

AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 μM) . AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1].

Product Specifications

CAS Number

[233605-81-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/av123.html

Purity

99.60

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=[N+](C1=CC=C2C(NC(NCCCC)=N2)=C1)[O-]

Molecular Formula

C11H14N4O2

Molecular Weight

234.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Benchekroun M, et al. Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1. Eur J Med Chem. 2020 Sep 1;201:112337.