Garcinone C (Standard)

Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active[1][2].

Product Specifications

CAS Number

[76996-27-5]

UNSPSC

12352005

Target

ATM/ATR; CDK; Hedgehog; Reference Standards; STAT

Type

Reference Standards

Related Pathways

Cell Cycle/DNA Damage; JAK/STAT Signaling; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/garcinone-c-standard.html

Smiles

CC(C)(O)CCC1=C(O)C(O)=CC(OC2=CC(O)=C(C/C=C(C)/C)C(O)=C23)=C1C3=O

Molecular Formula

C23H26O7

Molecular Weight

414.45

References & Citations

[1]Xia Y, et al. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E BP1 in nasopharyngeal carcinoma cells. Oncol Rep. 2018 Mar;39 (3) :1485-1493.