C16G2
C16G2 is a specific targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen Streptococcus mutans. C16G2 specifically recognizes and disrupts the bacterial cell membrane, causing small molecule leakage and loss of membrane potential, leading to bacterial killing. Unlike broad-spectrum antimicrobial peptides, C16G2 exhibits higher selectivity and efficacy against Streptococcus mutans[1].
Product Specifications
CAS Number
2154327-48-5
UNSPSC
12352209
Target
Antibiotic; Bacterial
Type
Peptides
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/c16g2.html
Smiles
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(NCC(NCC(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC5=CNC=N5)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CC=C(C=C6)O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N
Molecular Formula
C190H310N58O42
Molecular Weight
4078.93
References & Citations
[1]Kaplan CW, et al. Selective membrane disruption: mode of action of C16G2, a specifically targeted antimicrobial peptide. Antimicrob Agents Chemother. 2011 Jul;55 (7) :3446-52.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 2
Frequently Asked Questions
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