Ferroptosis inducer-4
Product Specifications
UNSPSC Description
Ferroptosis inducer-4 (Compound 5) is a ferroptosis (Ferroptosis) inducer with a structure featuring terminal double bonds introduced at the sn-2 position of phospholipids. Ferroptosis inducer-4 exhibits significant cytotoxicity towards HT-1080 cells, with an IC50 of 18 μM. This cytotoxic mechanism involves the generation of lipid peroxides and oxidative damage to the cell membrane triggered by the terminal double bonds. Ferroptosis inducer-4 can be used for research on ferroptosis regulation[1].
Target Antigen
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ferroptosis-inducer-4.html
Smiles
C[N+](C)(C)CCOP(OC[C@H](OC(CC/C=C/C=C)=O)COCCCCCCCCCCCCCCCCCC)([O-])=O
Molecular Weight
617.84
References & Citations
[1]Zhang Q, et al. Synthesis of Plasmalogen Derivatives with Unnatural Fatty Acids as Substrates for Ferroptosis Induction. ACS Chem Biol. 2024 Aug 8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161948/Ferroptosis-inducer-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161948/
Clinical Information
No Development Reported
Curated Selection
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