MAIT-203
MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.
Product Specifications
UNSPSC
12352209
Target
Drug Derivative
Type
Peptides
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mait-203.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(NCC(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)CC1=CC=C(C=C1)O)=O)CC2CCCC2)=O)C)=O)CCC(O)=O)=O)=O)NC(OCC3=CC=CC=C3)=O
Molecular Formula
C106H177N43O29
Molecular Weight
2517.85
References & Citations
[1]Haiming Jiang, et al. Peptidomimetic Inhibitors of APC-Asef Interaction Block Colorectal Cancer Migration. Nat Chem Biol. 2017 Sep;13 (9) :994-1001.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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