NF-κΒ activator 1
NF-κΒ activator 1 (compound 32) is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD) 2 mRNA expression[1].
Product Specifications
CAS Number
[2387524-59-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nf-κ-activator-1.html
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=CC(C2=CSC(NC3=CC=CC=C3F)=N2)=C1
Molecular Formula
C16H11FN2O2S
Molecular Weight
314.33
Precautions
H302, H315, H319
References & Citations
[1]Mathew B, et al. Structure-activity relationship (SAR) studies of N- (3-methylpyridin-2-yl) -4- (pyridin-2-yl) thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS [published online ahead of print, 2020 Oct 22]. Eur J Med Chem. 2020;112952.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB
Available Sizes
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