Saccharopine (hydrochloride)

Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis[1][2][3].

Product Specifications

Product Name Alternative

L-Saccharopine (hydrochloride)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/saccharopine-hydrochloride.html

Purity

99.84

Solubility

H2O : 175 mg/mL (ultrasonic)

Smiles

OC([C@H](CCC(O)=O)NCCCC[C@@H](C(O)=O)N)=O.[H]Cl

Molecular Formula

C11H21ClN2O6

Molecular Weight

312.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhou J, et, al. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. J Cell Biol. 2019 Feb 4;218 (2) :580-597.|[2]Leandro J, et, al. Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. J Cell Biol. 2019 Feb 4;218 (2) :391-392.|[3]Papes F, et, al. Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem J. 1999 Dec 1;344 Pt 2 (Pt 2) :555-63.