D-Phenylalanine

D-Phenylalanine is an atypical D-amino acid and an inhibitor of bacterial biofilm formation. D-Phenylalanine mainly replaces D-alanine (D-Ala) by incorporating into the fourth and fifth positions of bacterial peptidoglycan (PG), changing the cell wall structure, enhancing bacterial acid resistance and affecting biofilm formation. D-Phenylalanine may promote the secretion of peptide tyrosine tyrosine (PYY) in mammals by activating the intestinal GPR109B receptor. D-Phenylalanine can inhibit the maturation of microbial biofilms and promote the release of specific hormones. It can be used for antibacterial preservation, improving the yield of probiotics in the food industry, and studying appetite regulation and blood sugar control in metabolic diseases such as diabetes[1][2][3][4].

Product Specifications

CAS Number

[673-06-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/d-phenylalanine.html

Purity

99.93

Solubility

DMSO : 1 mg/mL (ultrasonic) |H2O : 4.17 mg/mL (ultrasonic)

Smiles

N[C@H](CC1=CC=CC=C1)C(O)=O

Molecular Formula

C9H11NO2

Molecular Weight

165.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu H, et al. d-Methionine and d-Phenylalanine Improve Lactococcus lactis F44 Acid Resistance and Nisin Yield by Governing Cell Wall Remodeling. Appl Environ Microbiol. 2020 Apr 17;86 (9) :e02981-19.|[2]Li E, et al. D-Phenylalanine inhibits biofilm development of a marine microbe, Pseudoalteromonas sp. SC2014. FEMS Microbiol Lett. 2016 Sep;363 (18) .|[3]Amin A, et al. Differential effects of L- and D-phenylalanine on pancreatic and gastrointestinal hormone release in humans: A randomized crossover study. Diabetes Obes Metab. 2021 Jan;23 (1) :147-157.|[4]Walsh NE, et al. Analgesic effectiveness of D-phenylalanine in chronic pain patients. Arch Phys Med Rehabil. 1986 Jul;67 (7) :436-9.