6-CEPN

6-CEPN is a RAS inhibitor. 6-CEPN can inhibit RAS activation by binding to Icmt binding sites. 6-CEPN has anticancer activity. 6-CEPN can block cancer cells in the G1 phase. 6-CEPN can induce autophagy and necrosis of Cancer cells (Icmt: isovalerylcysteine carboxymethyltransferase) [1].

Product Specifications

CAS Number

[1054549-73-3]

UNSPSC

12352005

Target

Autophagy; Cyclin G-associated Kinase (GAK) ; Ras

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/6-cepn.html

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1CC(OC2=C1C(O)=C(C(O)=C2)/C=C/C3=CC=CC=C3)C4=CC=C(C=C4)O

Molecular Formula

C23H18O5

Molecular Weight

374.39

References & Citations

[1]Zhao Y, et al. 6-C- (E-phenylethenyl) naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells[J].European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR), 2016, 68 (Null) .