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Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8)

Selected Variant

HY-P990107-01

Size: 1 mg

Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) is an TGF-β IgG antibody inhibitor. Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) reduces renal fibrosis in unilateral ureteral obstruction (UUO) mice models. Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) shows potent anti-tumor effect in various tumor models, such as pancreatic cancer[1][2][3][4].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

TGF-β Receptor

Type

Inhibitory Antibodies

Related Pathways

TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anti-mouse-human-rat-monkey-hamster-canine-bovine-tgf-β-antibody-1d11.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

[Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/BovineTGF-bAntibody(1D11.16.8)]

Molecular Weight

(150 kDa)

References & Citations

[1]Terra M, et al. Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling. Cancer Res. 2018 Jun 1;78 (11) :3014-3026.|[2]Malenica I, et al. Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade. Nat Commun. 2021 Sep 1;12 (1) :5209.|[3]McGaraughty S, et al. Targeting Anti-TGF-β Therapy to Fibrotic Kidneys with a Dual Specificity Antibody Approach. J Am Soc Nephrol. 2017 Dec;28 (12) :3616-3626.|[4]Greco SH, et al. TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia. PLoS One. 2015 Jul 14;10 (7) :e0132786.

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4°C for 2 years, do not freeze

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Available Sizes

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