BRD2879
BRD2879 is a potent IDH1-R132H inhibitor with IC50 values of 0.05, 2.5, >20, >20 µM for IDH1-R132H, IDH1-R132C, IDH1-WT, IDH2-R140Q, respectively. BRD2879 reduces (R) -2-hydroxyglutarate (R-2HG) levels[1].
Product Specifications
CAS Number
1304750-47-7
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd2879.html
Smiles
O=S1(C2=CC=C(C#CC3=CC(F)=CC=C3)C=C2O[C@H]([C@@H](CN1[C@@H](C)CO)C)CN(C)C(NC4CCCCC4)=O)=O
Molecular Formula
C30H38FN3O5S
Molecular Weight
571.70
References & Citations
[1]Law JM, et al. Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1. ACS Med Chem Lett. 2016 Aug 18;7 (10) :944-949.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH1; IDH2
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