(1R,3S) -Compound E

(1R,3S) -Compound E is the isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid (40), β-amyloid (42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.

Product Specifications

CAS Number

[504428-17-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1r-3s-compound-e.html

Purity

99.82

Solubility

DMSO : ≥ 50 mg/mL

Smiles

FC1=CC(F)=CC(CC(N[C@H](C)C(N[C@H]2N=C(C3=CC=CC=C3)C4=CC=CC=C4N(C2=O)C)=O)=O)=C1

Molecular Formula

C27H24F2N4O3

Molecular Weight

490.50

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276 (48) :45394-402.|[2]Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100 (12) :1879-88.