ML-9
ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].
Product Specifications
CAS Number
105637-50-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml-9.html
Purity
99.86
Solubility
DMSO : 83.33 mg/mL (ultrasonic) |H2O : ≥ 5 mg/mL
Smiles
O=S(N1CCNCCC1)(C2=C3C=CC=C(Cl)C3=CC=C2)=O.[H]Cl
Molecular Formula
C15H18Cl2N2O2S
Molecular Weight
361.29
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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