1-Dehydro-[10]-gingerdione
Product Specifications
UNSPSC Description
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research[1].
Target Antigen
IKK; NF-κB
Type
Natural Products
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-dehydro-10-gingerdione.html
Solubility
10 mM in DMSO
Smiles
O=C(CC(CCCCCCCCC)=O)/C=C/C1=CC=C(C(OC)=C1)O
Molecular Weight
346.46
References & Citations
[1]Hwa Young Lee, et al. 1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes. Br J Pharmacol. 2012 Sep;167(1):128-40.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N10768/1-Dehydro-10-gingerdione-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N10768/
Clinical Information
No Development Reported
CAS Number
136826-50-1
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