Selpercatinib (Standard)
Selpercatinib (Standard) is the analytical standard of Selpercatinib. This product is intended for research and analytical applications. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity[1][2].
Product Specifications
CAS Number
2152628-33-4
Product Name Alternative
LOXO-292 (Standard)
UNSPSC
12352005
Target
Reference Standards; RET
Type
Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/selpercatinib-standard.html
Smiles
N#CC1=C2C(C3=CC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OCC(C)(O)C)=CN2N=C1
Molecular Formula
C29H31N7O3
Molecular Weight
525.60
References & Citations
[1]Şentürk R, et, al. Quantitative bioanalytical assay for the selective RET inhibitors selpercatinib and pralsetinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Jun 15;1147:122131.|[2]Steven W. Andrews, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC401696-100 1x 100 µL
CTLA4 / CD152 (Negative Regulator of T-Cells) (L4P2F5.F10), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401892-100 1x 100 µL
CD10 (Membrane Metalloendopeptidase) (MME/1892), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details