KAAD-Cyclopamine
KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1].
Product Specifications
CAS Number
306387-90-6
Product Name Alternative
Cyclopamine-KAAD
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kaad-cyclopamine.html
Purity
96.0
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
C[C@H]([C@@](N1CCNC(CCCCCNC(CCC2=CC=CC=C2)=O)=O)([H])[C@](C[C@H](C)C1)([H])O3)[C@@]43C(C)=C(C[C@@]5([H])[C@@]6([H])CC=C(C7)[C@@]5(CCC7=O)C)[C@@]6([H])CC4
Molecular Formula
C44H63N3O4
Molecular Weight
697.99
Precautions
H302, H315, H319, H335
References & Citations
[1]Surajit Sinha, et al. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006 Jan;2 (1) :29-30.|[2]Xiaoli Ma, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005 Oct;26 (10) :1698-705.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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