KAAD-Cyclopamine

KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1].

Product Specifications

CAS Number

[306387-90-6]

Product Name Alternative

Cyclopamine-KAAD

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kaad-cyclopamine.html

Purity

96.0

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

C[C@H]([C@@](N1CCNC(CCCCCNC(CCC2=CC=CC=C2)=O)=O)([H])[C@](C[C@H](C)C1)([H])O3)[C@@]43C(C)=C(C[C@@]5([H])[C@@]6([H])CC=C(C7)[C@@]5(CCC7=O)C)[C@@]6([H])CC4

Molecular Formula

C44H63N3O4

Molecular Weight

697.99

Precautions

H302, H315, H319, H335

References & Citations

[1]Surajit Sinha, et al. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006 Jan;2 (1) :29-30.|[2]Xiaoli Ma, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005 Oct;26 (10) :1698-705.