Cycloguanil (hydrochloride)
Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].
Product Specifications
CAS Number
152-53-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cycloguanil-hydrochloride.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 62.5 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC(N)=NC(C)(N1C2=CC=C(C=C2)Cl)C.[H]Cl
Molecular Formula
C11H15Cl2N5
Molecular Weight
288.18
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
Citation 01
Antimicrob Agents Chemother. 2025 Aug 18:e0047125.|bioRxiv. 2025 March 15.|Pharmaceuticals (Basel) . 2024 Sep 19;17 (9) :1234.
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