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Cycloguanil (hydrochloride)

Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

Product Specifications

CAS Number

152-53-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cycloguanil-hydrochloride.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC(N)=NC(C)(N1C2=CC=C(C=C2)Cl)C.[H]Cl

Molecular Formula

C11H15Cl2N5

Molecular Weight

288.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105 (1) :190-200.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Plasmodium

Citation 01

Antimicrob Agents Chemother. 2025 Aug 18:e0047125.|bioRxiv. 2025 March 15.|Pharmaceuticals (Basel) . 2024 Sep 19;17 (9) :1234.

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