Human GLP1R Full Length Protein (L260F), Flag, His Tag (Detergent)

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke.

Product Specifications

Background

Specifications

This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 66.5 kDa.

Accession Number

P43220-1 (L260F)

Expression Region

Arg 24 - Ser 432

Host

HEK293

Target

GLP1R

Conjugation

Unconjugated

Tag

N-Flag & C-10xHis

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

1.0 EU per μg

Bioactivity

Immobilized Human GLP1R Full Length Protein, Flag,His Tag (Cat. No. GLR-H52D4) at 5 μg/mL (100 μL/well) on a Nickel Coated plate (Cat. No. SP-16) can bind Dulaglutide with a linear range of 0.5-16 ng/mL (QC tested).