JAK3 covalent inhibitor-2
JAK3 covalent inhibitor-2 (compound J1b) is a selective, orally potent JAK3 inhibitor (IC50=7.2 nM) with low toxicity, anti-inflammatory activity and good bioavailability[1].
Product Specifications
CAS Number
[2664050-97-7]
UNSPSC
12352005
Target
Apoptosis; JAK
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak3-covalent-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
[O-][N+](C1=CC=CC(C2=CNC3=NC=NC(N4C[C@H](NC(C=C)=O)CCC4)=C32)=C1)=O
Molecular Formula
C20H20N6O3
Molecular Weight
392.41
References & Citations
[1]Hualiang Y et al. Design and synthesis of highly selective Janus kinase 3 covalent inhibitors for the treatment of rheumatoid arthritis ARCH PHARM. 2024 Feb e2300753
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3
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