JAK3 covalent inhibitor-2

JAK3 covalent inhibitor-2 (compound J1b) is a selective, orally potent JAK3 inhibitor (IC50=7.2 nM) with low toxicity, anti-inflammatory activity and good bioavailability[1].

Product Specifications

CAS Number

[2664050-97-7]

UNSPSC

12352005

Target

Apoptosis; JAK

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jak3-covalent-inhibitor-2.html

Solubility

10 mM in DMSO

Smiles

[O-][N+](C1=CC=CC(C2=CNC3=NC=NC(N4C[C@H](NC(C=C)=O)CCC4)=C32)=C1)=O

Molecular Formula

C20H20N6O3

Molecular Weight

392.41

References & Citations

[1]Hualiang Y et al. Design and synthesis of highly selective Janus kinase 3 covalent inhibitors for the treatment of rheumatoid arthritis ARCH PHARM. 2024 Feb e2300753