Thalidomide-4-O-C2-NH2 (hydrochloride)

Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2341840-99-9]

UNSPSC

12352005

Hazard Statement

H301, H312, H361

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-4-o-c2-nh2-hydrochloride.html

Purity

99.37

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCN)=O.[H]Cl

Molecular Formula

C15H16ClN3O5

Molecular Weight

353.76

Precautions

H301, H312, H361

References & Citations

[1]Turk BE, et al. Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production. Proc Natl Acad Sci U S A. 1996;93 (15) :7552‐7556.