NP3-562
NP3-562 is an orally active NLRP3 Inhibitor. NP3-562 inhibits IL-1β release in the supernatant of Nigericin (HY-127019) -stimulated THP-1 cells (IC50 = 66 nM), human whole blood (IC50 = 214 nM) and a mouse acute peritonitis model. NP3-562 can be used for the study of acute peritonitis[1].
Product Specifications
CAS Number
[2409825-32-5]
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/np3-562.html
Purity
98.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(O)(C(N1C2=C(SC(Cl)=C2)C=C13)=NN(CC(N[C@H]4CN(CCC4)C)=O)C3=O)C
Molecular Formula
C19H24ClN5O3S
Molecular Weight
437.94
References & Citations
[1]Juraj Velcicky, et al. Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors. J Med Chem. 2024 Jan 4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; NLRP3
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Lentiviral human NRGN shRNA (UAS) - Lentiviral human NRGN shRNA (UAS, RFP) (100)
Recombinant Chlamydia trachomatis Transaldolase (tal)
Recombinant Chlamydia trachomatis Transaldolase (tal)
Recombinant Chlamydia trachomatis Transaldolase (tal)