PRMT5-IN-45
Product Specifications
UNSPSC Description
PRMT5-IN-45 (compound 36) is a potent and selective PRMT5 inhibitor with an IC50 of 3 nM. PRMT5-IN-45 potently reduces the level of symmetric dimethylarginines (sDMA) and inhibits the proliferation of MOLM-13 cell lines by inducing apoptosis and cell cycle arrest[1].
Target Antigen
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prmt5-in-45.html
Smiles
O[C@@H]1[C@H](O)[C@@H](CCC2=CC=C3C=CC(N)=NC3=C2)C[C@H]1N4C=CC5=C(N6CCNCC6)N=CN=C54
Molecular Weight
473.57
References & Citations
[1]Huaxuan Li, et al. One stone two birds: Introducing piperazine into a series of nucleoside derivatives as potent and selective PRMT5 inhibitors. Eur J Med Chem. 2024 Oct 19:281:116970.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168263/PRMT5-IN-45-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168263/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7189478 Inquire
Rabbit anti-Escherichia coli O6:K15:H31 (strain 536/UPEC) GATY Polyclonal Antibody
Ask
View Details 
45914126 3 x 1.0μg DNA
SUV420H2 CRISPRa sgRNA lentivector (set of three targets)(Rat)
Ask
View Details