(1-Nitroethene-1,2-diyl) dibenzene
(1-Nitroethene-1,2-diyl) dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50=11 μM in histone H4 methylation assay) . It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, at concentrations of 10 and 100 μM.
Product Specifications
CAS Number
[1215-07-2]
Product Name Alternative
Alpha-Nitrostilbene; α-Nitrostilbene; NSC 385
UNSPSC
12352005
Hazard Statement
H302
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/1-nitroethene-1-2-diyl-dibenzene.html
Smiles
O=[N+](/C(C1=CC=CC=C1)=C/C2=CC=CC=C2)[O-]
Molecular Formula
C14H11NO2
Molecular Weight
225.24
Precautions
P264-P270-P330-P501
References & Citations
[1]Dillon, et al. Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization. ACS Chem. Biol. 7 (7), 1198-1204 (2012) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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