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(1-Nitroethene-1,2-diyl) dibenzene

(1-Nitroethene-1,2-diyl) dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50=11 μM in histone H4 methylation assay) . It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, at concentrations of 10 and 100 μM.

Product Specifications

CAS Number

[1215-07-2]

Product Name Alternative

Alpha-Nitrostilbene; α-Nitrostilbene; NSC 385

UNSPSC

12352005

Hazard Statement

H302

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-nitroethene-1-2-diyl-dibenzene.html

Smiles

O=[N+](/C(C1=CC=CC=C1)=C/C2=CC=CC=C2)[O-]

Molecular Formula

C14H11NO2

Molecular Weight

225.24

Precautions

P264-P270-P330-P501

References & Citations

[1]Dillon, et al. Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization. ACS Chem. Biol. 7 (7), 1198-1204 (2012) .

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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