A-1210477

A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM[1]. A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner[2].

Product Specifications

CAS Number

[1668553-26-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

Apoptosis; Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/A-1210477.html

Purity

99.86

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C(C(N1CCN2CCOCC2)=C(CCCOC3=C4C=CC=CC4=CC=C3)C5=C1C(C6=C(COC7=CC=C(N8CCN(S(=O)(N(C)C)=O)CC8)C=C7)N(C)N=C6C)=CC=C5)O

Molecular Formula

C46H55N7O7S

Molecular Weight

850.04

Precautions

H302, H315, H320, H335

References & Citations

[1]Leverson JD, et al. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) . Cell Death Dis. 2015 Jan 15;6:e1590.|[2]Qing Wang, et al. A-1210477, a selective MCL-1 inhibitor, overcomes ABT-737 resistance in AML. Oncol Lett. 2019 Nov;18 (5) :5481-5489.