CCR4 antagonist 4
CCR4 antagonist 4 (compound 22) is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC50 of 0.02 μM. CCR4 antagonist 4 also blocks MDC-mediated chemotaxis (IC50: 0.007 μM) and Ca2+ mobilization (IC50: 0.003 μM) . CCR4 antagonist 4 can be used for allergic inflammation research[1].
Product Specifications
CAS Number
[668980-17-4]
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ccr4-antagonist-4.html
Purity
99.72
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC(C=C(C=C1)Cl)=C1CNC2=NC(N3CCN(CC3)C([C@H]4CCCCN4)=O)=NC5=C2C=CC=N5
Molecular Formula
C24H27Cl2N7O
Molecular Weight
500.42
References & Citations
[1]Purandare AV, et al. Core exploration in optimization of chemokine receptor CCR4 antagonists. Bioorg Med Chem Lett. 2007 Feb 1;17 (3) :679-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR4
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GOLPH3, CT (Golgi Phosphoprotein 3, Coat Protein GPP34, FLJ90675, GPP34, GOPP1, Mitochondrial DNA Absence Factor, MIDAS) (MaxLight 750)
GOLPH3, CT (Golgi Phosphoprotein 3, Coat Protein GPP34, FLJ90675, GPP34, GOPP1, Mitochondrial DNA Absence Factor, MIDAS) (MaxLight 750)