Mouse GUCY2C / Guanylyl cyclase C Protein, His Tag (MALS verified)
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
Product Specifications
Background
Specifications
Accession Number
Q3UWA6-1
Expression Region
Val 20 - Met 433
Host
HEK293
Target
GUCY2C
Conjugation
Unconjugated
Tag
C-10xHis
Source
Mouse
Stability
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
49.0 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
1mg*1
Host or Source
HEK293
Species
Mouse
Protein ID
Q3UWA6-1
Preservative
Trehalose
Explore Other Products
Browse additional items from our catalog
Donkey Ig Lambda-7 Chain C Region (IGLC7) ELISA Kit
Insulin-Like Growth Factor I Receptor (IGF1R) (AP) discontinued
Lentiviral mouse Neurod4 shRNA (UAS) - Lentiviral mouse Neurod4 shRNA (UAS) (25)