Cyclo (his-pro) (TFA)

Cyclo (his-pro) TFA (Cyclo (histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo (his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo (his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].

Product Specifications

CAS Number

[936749-56-3]

Product Name Alternative

Cyclo (histidyl-proline) (TFA) ; Histidylproline diketopiperazine (TFA)

UNSPSC

12352209

Target

Endogenous Metabolite; NF-κB

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cyclo-his-pro-tfa.html

Purity

99.13

Solubility

DMSO : 260 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic; adjust pH to 10 with NaOH)

Smiles

OC(C(F)(F)F)=O.O=C(N[C@H]1CC2=CN=CN2)[C@@](CCC3)([H])N3C1=O

Molecular Formula

C13H15F3N4O4

Molecular Weight

348.28

References & Citations

[1]Grottelli S, et al. The Role of Cyclo (His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17 (8) . pii: E1332.|[2]Minelli A, et al. Cyclo (His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. Int J Biochem Cell Biol. 2012 Mar;44 (3) :525-35.|[3]Bellezza I, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo (His-Pro) to prevent LPS neurotoxicity. Int J Biochem Cell Biol. 2014 Jun;51:159-69.