Cyclo (his-pro) (TFA)
Cyclo (his-pro) TFA (Cyclo (histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo (his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo (his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].
Product Specifications
CAS Number
936749-56-3
Product Name Alternative
Cyclo (histidyl-proline) (TFA) ; Histidylproline diketopiperazine (TFA)
UNSPSC
12352209
Target
Endogenous Metabolite; NF-κB
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cyclo-his-pro-tfa.html
Purity
99.13
Solubility
DMSO : 260 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic; adjust pH to 10 with NaOH)
Smiles
OC(C(F)(F)F)=O.O=C(N[C@H]1CC2=CN=CN2)[C@@](CCC3)([H])N3C1=O
Molecular Formula
C13H15F3N4O4
Molecular Weight
348.28
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; NF-κB
Available Sizes
Frequently Asked Questions
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